Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene

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Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene.

Styrene-specific N-7- and O6-guanine DNA adducts and N-terminal valine adducts were determined in mice tissues after the intraperitoneal administration of styrene. Blood, liver, lungs and spleen were collected 3 h after administration of various doses (from 0 to 4.35 mmol/kg b.w.) of styrene. DNA adducts were analysed by the modified 32P-postlabelling assay and N-terminal valine adducts were de...

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ژورنال

عنوان ژورنال: Carcinogenesis

سال: 1996

ISSN: 0143-3334,1460-2180

DOI: 10.1093/carcin/17.12.2673